COVID-19 Vaccine In Pregnancy and Lactation (COVIPAL)

To address the lack of data on vaccine efficacy and safety in pregnant and lactating populations, our team launched a study of immune response and pregnancy outcomes after COVID-19 Vaccine in Pregnancy and Lactation (COVIPAL) in early 2021.

FAQs

I was vaccinated but I got a COVID-19 breakthough infection. Am I eligible?

I was vaccinated prior to pregnancy, but I am currently pregnant and planning to get a booster. Am I eligible?

I was vaccinated during my recent pregnancy, and I am planning to get a booster. Am I eligible?

Is there compensation for participating in the study?

Can I get my antibody results through participation in the study?

How long will the study be running?

Do you have any results of your study yet?

Here are the results that have been published so far:

Nirmatrelvir-Ritonavir (Paxlovid) for Mild Coronavirus Disease 2019 (COVID-19) in Pregnancy and Lactation.
Lin CY, Cassidy AG, Li L, Prahl MK, Golan Y, Gaw SL. Obstet Gynecol. 2023 Mar 16. doi: 10.1097/AOG.0000000000005152. Epub ahead of print. PMID: 36928334.
Minimal mRNA uptake and inflammatory response to COVID-19 mRNA vaccine exposure in human placental explants.
Gonzalez V, Li L, Buarpung S, Prahl M, Robinson JF, Gaw SL. medRxiv. 2023 Feb 2;. doi: 10.1101/2023.02.01.23285349. PubMed PMID: 36778281; PubMed Central PMCID: PMC9915836
Milk antibody response after 3rd dose of COVID-19 mRNA vaccine and SARS-CoV-2 breakthrough infection and implications for infant protection.
Golan Y, Ilala M, Gay C, Hunagund S, Lin CY, Cassidy AG, Jigmeddagva U, Li L, Ozarslan N, Asiodu IV, Ahituv N, Flaherman VJ, Gaw SL, Prahl M. . medRxiv. 2022 Dec 14;. doi: 10.1101/2022.12.12.22283367. PubMed PMID: 36561188; PubMed Central PMCID: PMC9774223.
Patterns of Peripartum Depression and Anxiety During the Pre-Vaccine COVID-19 Pandemic.
Altendahl MR, Xu L, Asiodu I, Boscardin J, Gaw SL, Flaherman VJ, Jacoby VL, Richards MC, Krakow D, Afshar Y. Res Sq. 2022 Dec 13;. doi: 10.21203/rs.3.rs-2294673/v1. PubMed PMID: 36561172; PubMed Central PMCID: PMC9774217.
Evaluation of transplacental transfer of mRNA vaccine products and functional antibodies during pregnancy and infancy.
Prahl M, Golan Y, Cassidy AG, Matsui Y, Li L, Alvarenga B, Chen H, Jigmeddagva U, Lin CY, Gonzalez VJ, Chidboy MA, Warrier L, Buarpung S, Murtha AP, Flaherman VJ, Greene WC, Wu AHB, Lynch KL, Rajan J, Gaw SL. Nat Commun. 2022 Jul 30;13(1):4422. doi: 10.1038/s41467-022-32188-1. PMID: 35908075; PMCID: PMC9338928.
Effects of Vaccination Against Influenza, Pertussis, and COVID-19 on Human Milk Antibodies: Current Evidence and Implications for Health Equity.
Hunagund S, Golan Y, Asiodu IV, Prahl M, Gaw SL. Front Immunol. 2022 Jul 12;13:910383. doi: 10.3389/fimmu.2022.910383. PMID: 35903100; PMCID: PMC9314549.
Neutralizing antibody activity against SARS-CoV-2 variants in gestational age-matched mother-infant dyads after infection or vaccination.
Matsui Y, Li L, Prahl M, Cassidy AG, Ozarslan N, Golan Y, Gonzalez VJ, Lin CY, Jigmeddagva U, Chidboy MA, Montano M, Taha TY, Khalid MM, Sreekumar B, Hayashi JM, Chen PY, Kumar GR, Warrier L, Wu AH, Song D, Jegatheesan P, Rai DS, Govindaswami B, Needens J, Rincon M, Myatt L, Asiodu IV, Flaherman VJ, Afshar Y, Jacoby VL, Murtha AP, Robinson JF, Ott M, Greene WC, Gaw SL. JCI Insight. 2022 Jun 22;7(12):e157354. doi: 10.1172/jci.insight.157354. PMID: 35579965.
Early non-neutralizing, afucosylated antibody responses are associated with COVID-19 severity.
Chakraborty S, Gonzalez JC, Sievers BL, Mallajosyula V, Chakraborty S, Dubey M, Ashraf U, Cheng BY, Kathale N, Tran KQT, Scallan C, Sinnott A, Cassidy A, Chen ST, Gelbart T, Gao F, Golan Y, Ji X, Kim-Schulze S, Prahl M, Gaw SL, Gnjatic S, Marron TU, Merad M, Arunachalam PS, Boyd SD, Davis MM, Holubar M, Khosla C, Maecker HT, Maldonado Y, Mellins ED, Nadeau KC, Pulendran B, Singh U, Subramanian A, Utz PJ, Sherwood R, Zhang S, Jagannathan P, Tan GS, Wang TT. Sci Transl Med. 2022 Jan 18:eabm7853. doi: 10.1126/scitranslmed.abm7853. Epub ahead of print. PMID: 35040666.
Antibodies elicited by SARS-CoV-2 infection or mRNA vaccines have reduced neutralizing activity against Beta and Omicron pseudoviruses.
Sievers BL, Chakraborty S, Xue Y, Gelbart T, Gonzalez JC, Cassidy AG, Golan Y, Prahl M, Gaw SL, Arunachalam PS, Blish CA, Boyd SD, Davis MM, Jagannathan P, Nadeau KC, Pulendran B, Singh U, Scheuermann RH, Frieman MB, Vashee S, Wang TT, Tan GS. Sci Transl Med. 2022 Jan 13:eabn7842. doi: 10.1126/scitranslmed.abn7842. Epub ahead of print. PMID: 35025672.
COVID-19 mRNA Vaccination in Lactation: Assessment of Adverse Events and Vaccine Related Antibodies in Mother-Infant Dyads.
Golan Y, Prahl M, Cassidy AG, Gay C, Wu AHB, Jigmeddagva U, Lin CY, Gonzalez VJ, Basilio E, Chidboy MA, Warrier L, Buarpung S, Li L, Murtha AP, Asiodu IV, Ahituv N, Flaherman VJ, Gaw SL. Front Immunol. 2021 Nov 3;12:777103. doi: 10.3389/fimmu.2021.777103. PMID: 34804068; PMCID: PMC8595828.
Evaluating COVID-19 Vaccine-Related Messenger RNA in Breast Milk-Reply.
Golan Y, Flaherman VJ, Gaw SL. Evaluating COVID-19 Vaccine-Related Messenger RNA in Breast Milk-Reply. JAMA Pediatr. 2021 Oct 18. doi: 10.1001/jamapediatrics.2021.4087. Epub ahead of print. PMID: 34661610.
Evaluation of Messenger RNA From COVID-19 BTN162b2 and mRNA-1273 Vaccines in Human Milk.
Golan Y, Prahl M, Cassidy A, Lin CY, Ahituv N, Flaherman VJ, Gaw SL. Evaluation of Messenger RNA From COVID-19 BTN162b2 and mRNA-1273 Vaccines in Human Milk. JAMA Pediatr. 2021 Jul 6. doi: 10.1001/jamapediatrics.2021.1929. Epub ahead of print. PMID: 34228115.

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COVID-19 Vaccine In Pregnancy and Lactation (COVIPAL)

To address the lack of data on vaccine efficacy and safety in pregnant and lactating populations, our team launched a study of immune response and pregnancy outcomes after COVID-19 Vaccine in Pregnancy and Lactation (COVIPAL) in early 2021.

FAQs